Cancer Therapy: Preclinical Enhancement of 5-Fluorouracil-induced In Vitro and In Vivo Radiosensitization with MEK Inhibition

نویسندگان

  • Mary Ellen Urick
  • Eun Joo Chung
  • William P. Shield
  • Naamit Gerber
  • Ayla White
  • Anastasia Sowers
  • Angela Thetford
  • Kevin Camphausen
  • James Mitchell
  • Deborah E. Citrin
چکیده

Purpose: Gastrointestinal cancers frequently exhibit mutational activation of the Ras/MAPK pathway, which is implicated in resistance to ionizing radiation (IR) and chemotherapy. Concurrent radiotherapy and 5-fluorouracil (5-FU) based chemotherapy is commonly used for treatment of gastrointestinal malignancies. We previously reported radiosensitization with selumetinib, an inhibitor of MEK1/2. The purpose of the current study was to evaluate if selumetinib could enhance radiosensitivity induced

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تاریخ انتشار 2011